Mendelian randomization and pleiotropy analysis
نویسندگان
چکیده
منابع مشابه
Pleiotropy-robust Mendelian randomization.
Background The potential of Mendelian randomization studies is rapidly expanding due to: (i) the growing power of genome-wide association study (GWAS) meta-analyses to detect genetic variants associated with several exposures; and (ii) the increasing availability of these genetic variants in large-scale surveys. However, without a proper biological understanding of the pleiotropic working of ge...
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A fundamental assumption in inferring causality of an exposure on complex disease using Mendelian randomization (MR) is that the genetic variant used as the instrumental variable cannot have pleiotropic effects. Violation of this ‘no pleiotropy’ assumption can cause severe bias. Emerging evidence have supported a role for pleiotropy amongst disease-associated loci identified from GWA studies. H...
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Background: Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods. Methods: The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations o...
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GMRP can perform analyses of Mendelian randomization (MR),correlation, path of causal variables onto disease of interest and SNP annotation analysis. MR includes SNP selection with given criteria and regression analysis of causal variables on the disease to generate beta values of causal variables on the disease. Using the beta vectors, GMRP performs correlation and path analyses to construct p...
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Background Mendelian randomization (MR) is being increasingly used to strengthen causal inference in observational studies. Availability of summary data of genetic associations for a variety of phenotypes from large genome-wide association studies (GWAS) allows straightforward application of MR using summary data methods, typically in a two-sample design. In addition to the conventional inverse...
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ژورنال
عنوان ژورنال: Quantitative Biology
سال: 2020
ISSN: 2095-4689,2095-4697
DOI: 10.1007/s40484-020-0216-3